Amitriptyline is a tricyclic antidepressant used to treat depression and, off-label, conditions like insomnia, anxiety, migraines, and chronic pain. What is this medication? AMITRIPTYLINE (a mee TRIP ti leen) treats depression. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called tricyclic antidepressants (TCAs). Amitriptyline is indicated for the treatment of major depressive disorder, neuropathic pain, and for the prevention of migraine and chronic tension headache. It can be used for the treatment of nocturnal enuresis in children older than 6 after other treatments have failed. [11] Amitriptyline is a type of medicine called a tricyclic antidepressant (TCA). These medications work by increasing certain brain chemicals called neurotransmitters like serotonin and. Amitriptyline is a prescription medication used to treat mental/mood problems such as Depression. Amitriptyline is available under the following different brand names: Elavil, Levate Find patient medical information for Amitriptyline (Amitid, Elavil, Endep) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Why is this medication prescribed? Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. Amitriptyline may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away. Detailed Amitriptyline dosage information for adults, the elderly and children. Includes dosages for Depression; plus renal, liver and dialysis adjustments. Find out how amitriptyline treats pain and prevents migraine and how to take it. NHS medicines information on amitriptyline – what it's used for, side effects, dosage and who can take it.